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KMID : 1007520100190051391
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Food Science and Biotechnology
2010 Volume.19 No. 5 p.1391 ~ p.1395
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Effect of Licorice (Glycyrrhiza uralensis Fisch) on Amyloid-β-induced Neurotoxicity in PC12 Cells
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Ahn Ji-Yun
Kim Sun-A
Jung Sung-Eun
Ha Tae-Youl
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Abstract
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Alzheimer’s disease is characterized by neuronal loss and the presence of extracellular senile plaques whose major constituent is amyloid-β peptide (Aβ). In this study, we investigated the effects of a water extract of licorice (Glycyrrhiza uralensis F.) (GWE) on Aβ25-35-induced apoptosis in PC12 cells. Exposure to Aβ25-35-induced apoptosis, such as decreased mitochondrial transmembrane potential, increased lipid peroxide formation, decreased antiapoptotic bcl-2 and poly(ADP-ribose) polymerase, and elevated proapoptotic bax, and caspase-3. However, treatment of GWE effectively decreased cell deaths evoked by Aβ25-35. This result suggests that GWE exerts protective effect against apoptotic neuronal cell death induced by Aβ fragments.
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KEYWORD
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licorice (Glycyrrhiza uralensis Fisch), neuroprotective effect, apoptosis, Alzheimer’s disease
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